Citations for the video on boldenone, which you can watch here.
A. 17-beta-Boldenone, also 1-dehydrotestosterone and androsta-1,4-diene-17beta-ol-3-one, differs from 17-beta-testosterone by having only one double bond at the 1-position. As a veterinary steroid, boldenone is produced with an undecylenate ester, which testosterone was once produced with also.
B. From a single injection of testosterone, undecylenate produces maximal androgenic effect in roosters (judged by the size of the comb on their heads) after 17 days, after which it slowly declines. For reference, propionate hits its max (lower than undecylenate) at 6 days.
C. Developed for human use as Parenabol.
D. Where testosterone has a 31% affinity to the human recombinant androgen receptor (as compared to 100% for dihydrotestosterone), boldenone has a 49% affinity. It has less than a 1/4th the affinity for the bovine progesterone receptor as testosterone and about 100x less than 19-nortesterone. It binds to recombinant human SHBG about 50% more than testosterone, but far less than 19-nortestosterone. The efficacy of boldenone to the human androgen receptor is unknown.
E. Boldenone is naturally produced in male animals, though it is not entirely clear how food and micro-organisms affect its synthesis in animals.
F. Boldenone causes hepatic dysfunction in rabbits, elevating serum transaminase values (ALT and AST), which return to normal following discontinuation.
G. In rats, boldenone increased serum creatinine and LDL-C. Anti-nitrogen species phytochemicals from grapeseed extract reduced the cardiotoxicity of boldenone on rats.
H. Interestingly, moringa leaf extract has been shown to attenuate renal and hepatic damage due to boldenone.
I. Boldenone disrupts the HPG systems of rabbits, though it does not appear to harm sperm morphology.
J. Per mg, boldenone produced more acetylcholinesterase activity than controls and more than stanozolol (brand name Winstrol) and the effect was more pronounced with time. In the long-term, it produces more oxidative stress than stanozolol in the cerebral cortex and produced more aggressive behavior than stanozolol. It also worsened memory, unlike stanozolol.
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